Nick Kyrgios, Carlos Alcaraz, Jannik Sinner and Casper Ruud are the top favorites to win the US Open according to bet365.

Here are the latest odds:

Nick Kyrgios 2.60
Carlos Alcaraz 3.25
Jannik Sinner 5.50
Casper Ruud 11.00
Matteo Berrettini 11.00
Frances Tiafoe 15.00
Andrey Rublev 15.00
Karen Khachanov 26.00

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Kyrgios at the U.S. Open, ranking, and results in 2022

Now ranked no.25, Kyrgios has an overall 35-9 win-loss record in 2022. Nick is now having a run at the U.S. Open where he managed to beat the world no.70 Thanasi Kokkinakis 6-3 6-4 7-6⁴, the world no.50 Benjamin Bonzi 7-6³ 6-4 4-6 6-4, the world no.87 Jeff Wolf 6-4 6-2 6-3 and the world no.1 Daniil Medvedev 7-6¹¹ 3-6 6-3 6-2.

Nick Kyrgios will face the world no.31 Karen Khachanov in the quarter on Tuesday at 9:00 pm on Arthur Ashe Stadium. Their actual record is 1-1.

Kyrgios clinched 1 title in 2022 in Washington. Kyrgios got to the final in Wimbledon.

Kyrgios won 7 titles in his career: 6 on hard courts and 1 on indoor courts. (See the list of his titles)

Alcaraz at the U.S. Open, ranking, and results in 2022

Now ranked no.4 (career-high), Alcaraz has a compiled 48-9 win-loss record in 2022. Carlos is currently playing at the U.S. Open where he overcame the world no.37 Sebastian Baez 7-5 7-5 2-0 ret., the world no.78 Federico Coria 6-2 6-1 7-5, the world no.43 Jenson Brooksby 6-3 6-3 6-3 and the world no.17 Marin Cilic 6-4 3-6 6-4 4-6 6-3.

Carlos Alcaraz will compete against the world no.13 Jannik Sinner in the quarter. Their current head to head is 2-2.

Alcaraz has won 4 titles in 2022 in Rio de Janeiro, in Miami, in Barcelona and in Madrid. The Spaniard was the finalist in Hamburg (Hamburg European Open) and in Umag (Plava Laguna Croatia Open).

Carlos won 5 titles in his career: 1 on hard courts and 4 on clay courts. (See the list of his titles)

Nick Kyrgios and Carlos Alcaraz have never clashed against each other.

Sinner at the U.S. Open, ranking, and results in 2022

At the moment ranked no.13, Jannik achieved a 42-11 match record in 2022. Sinner is now competing at the U.S. Open where he beat the world no.93 Daniel Altmaier 5-7 6-2 6-1 3-6 6-1, the world no.145 Christopher Eubanks 6-4 7-6⁸ 6-2, the world no.69 Brandon Nakashima 3-6 6-4 6-1 6-2 and the world no.73 Ilya Ivashka 6-1 5-7 6-2 4-6 6-3.

Jannik Sinner will play the world no.4 Carlos Alcaraz in the quarter. Their head to head is 2-2.

Sinner has won 1 title in 2022 in Umag.

The Italian won 6 titles in his career: 2 on hard courts, 1 on clay courts and 3 on indoor courts. (See the list of his titles)

Ruud at the U.S. Open, ranking, and results in 2022

Now ranked no.7, the Norwegian owns a composed 42-15 match record in 2022. Ruud is now competing at the U.S. Open where he ousted the world no.601 Kyle Edmund 6-3 7-5 6-2, the world no.117 Tim Van Rijthoven 6-7⁴ 6-4 6-4 6-4, the world no.34 Tommy Paul 7-6³ 6-7⁵ 7-6² 5-7 6-0 and the world no.112 Corentin Moutet 6-1 6-2 6-7⁴ 6-2.

Casper Ruud will compete against the world no.14 Matteo Berrettini in the quarter on Tuesday at 12:00 pm on Arthur Ashe Stadium. Their actual head to head record is 3-2 for Ruud.

Casper has won 3 titles in 2022 in Buenos Aires, in Geneva and in Gstaad. Casper reached the final in Miami (Miami Open) and at the French Open.

Casper won 9 titles in his career: 1 on hard courts and 8 on clay courts. (See the list of his titles)

Jannik Sinner and Casper Ruud played each other twice. The head to head is 2-0 for Sinner. The last time they squared off, Jannik Sinner won 7-5 6-1 in the quarter in Vienna (Erste Bank Open) in October 2021.

Here the video highlights.