Stefanos Tsitsipas and Alexandre Muller will fight against each other in the 1^st round of the U.S. Open for the 3^rd time in their career. They are scheduled to compete on Tuesday at 4:00 pm on Court 7. In the following paragraphs, you can find the head to head analysis and prediction.

Prediction, odds and live streaming

The pick for Tennis Tonic is Stefanos Tsitsipas who should win in 5 sets.

As per the initial odds, Stefanos Tsitsipas is the pick to win this match.
Stefanos Tsitsipas -> 1.56
Alexandre Muller -> 2.43

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Prediction and head to head Stefanos Tsitsipas vs. Alexandre Muller

This will be the 3^rd time that Stefanos Tsitsipas and Alexandre Muller face off. The head to head is 2-0 for Tsitsipas (see full H2H stats), 1-0 on hard.

The last time that they competed against each other, Tsitsipas won 6-2 7-6(3) in the 2^nd round in Rome back in May 2025.

Highlights Stefanos Tsitsipas vs Alexandre Muller – Rome 09-May-2025

Stefanos Tsitsipas

Ranked no. 28, Tsitsipas will start his run at the U.S. Open after he played his last match in Winston Salem where he lost 6-3 6-2 to Yunchaokete in the 2^nd round on the 19^th of August.

Stefanos has a composed 20-16 win-loss record in 2025, 10-8 on hard (See FULL STATS).

His best result of the current season was winning the title in Dubai where he defeated Felix Auger-Aliassime in the final 6-3 6-3.

Talking about his overall career, Tsitsipas has an overall 509-241 record. He has a positive 191-104 record on hard.

Previously at the U.S. Open

Previously, his best result was reaching the 3^rd round in 2020 and 2021. See his history.

Alexandre Muller

Ranked no. 38 (career-high), the French player will start his run at the New York after he played his last match in Winston Salem where he lost 6-3 6-2 to Mpetshi in the 3^rd round on the 20^th of August.

Muller has an overall 22-22 win-loss record in 2025, 11-9 on hard (See FULL STATS).

His best result of the current season was winning the title in Hong Kong where he defeated Kei Nishikori in the final 2-6 6-1 6-3.

In terms of his career, The French player has an overall 420-293 record. He has a positive 131-85 record on hard.

Previously at the U.S. Open

Previously, his best result was reaching the 2^nd round in 2024. See his history.

Tennis Scores – U.S. Open

• Taylor FritzFritz – Emilio NavaNava (7-5 6-2 6-3) – Stats, scores, rankings
• Ugo BlanchetBlanchet – Fabian MarozsanMarozsan (6-4 3-6 7-6⁷ 6-2) – Stats, scores, rankings
• Marcos GironGiron – Mariano NavoneNavone (6-0 7-5 4-6 5-7 6-4) – Stats, scores, rankings
• Pablo Carreno-BustaCarreno-Busta – Pablo Llamas RuizLlamas Ruiz (7-6⁷ 6-4 6-2) – Stats, scores, rankings
• Tomas MachacMachac – Luca NardiNardi (6-3 6-1 6-1) – Stats, scores, rankings
• Luciano DarderiDarderi – Rinky HijikataHijikata (6-2 6-1 6-2) – Stats, scores, rankings
• Novak DjokovicDjokovic – Learner TienTien (6-1 7-6³ 6-2) – Stats, scores, rankings
• Zachary SvajdaSvajda – Zsombor PirosPiros (6-4 6-2 7-5) – Stats, scores, rankings
• Ben SheltonShelton – Ignacio BuseBuse (6-3 6-2 6-4) – Stats, scores, rankings
• Adrian MannarinoMannarino – Tallon GriekspoorGriekspoor (7-5 6-4 6-0) – Stats, scores, rankings
• Tomas Martin EtcheverryMartin Etcheverry – Camilo Ugo CarabelliUgo Carabelli (6-3 6-2 6-0) – Stats, scores, rankings
• Jakub MensikMensik – Nicolas JarryJarry (7-6⁵ 6-3 6-4) – Stats, scores, rankings
• Benjamin BonziBonzi – Daniil MedvedevMedvedev (6-3 7-5 6-7⁵ 0-6 6-4) – Stats, scores, rankings
• Arthur RinderknechRinderknech – Roberto Carballes BaenaCarballes Baena (7-6² 7-5 4-6 6-2) – Stats, scores, rankings
• Brandon NakashimaNakashima – Jesper De JongDe Jong (6-2 6-7⁵ 2-6 6-2 7-6⁷) – Stats, scores, rankings
• Eliot SpizzirriSpizzirri – Stefan DostanicDostanic (7-5 6-4 7-6⁴) – Stats, scores, rankings
• Jordan ThompsonThompson – Corentin MoutetMoutet (6-2 6-4 1-6 6-3) – Stats, scores, rankings
• Jerome KymKym – Ethan QuinnQuinn (6-3 6-2 3-6 7-6⁵) – Stats, scores, rankings
• Jiri LeheckaLehecka – Borna CoricCoric (3-6 6-4 7-6⁵ 6-1) – Stats, scores, rankings
• Alejandro Davidovich FokinaDavidovich Fokina – Alexander ShevchenkoShevchenko (6-1 6-1 6-2) – Stats, scores, rankings

Upcoming matches in the draw

• Roberto Bautista AgutBautista Agut – Jacob FearnleyFearnley (0-0) – H2H and prediction
• Gael MonfilsMonfils – Roman SafiullinSafiullin (0-0) – H2H and prediction
• Novak DjokovicDjokovic – (0-0) – H2H and prediction
• James DuckworthDuckworth – Tristan BoyerBoyer (0-0) – H2H and prediction
• Marton FucsovicsFucsovics – Denis ShapovalovShapovalov (2-2) – H2H and prediction
• Jan-Lennard StruffStruff – Mackenzie McdonaldMcdonald (0-0) – H2H and prediction
• Hugo DellienDellien – Kamil MajchrzakMajchrzak (1-1) – H2H and prediction
• Jordan ThompsonThompson – Adrian MannarinoMannarino (4-6) – H2H and prediction
• Alexander ZverevZverev – Alejandro TabiloTabilo (1-0) – H2H and prediction
• Alexander BublikBublik – Marin CilicCilic (0-3) – H2H and prediction
• Botic Van De ZandschulpVan De Zandschulp – Holger Vitus Nodskov RuneVitus Nodskov Rune (0-2) – H2H and prediction
• Christopher O ConnellO Connell – Alex De MinaurDe Minaur (0-0) – H2H and prediction
• Quentin HalysHalys – David GoffinGoffin (0-1) – H2H and prediction
• Karen KhachanovKhachanov – (0-0) – H2H and prediction
• Daniel Elahi GalanElahi Galan – (1-0) – H2H and prediction
• Sebastian OfnerOfner – Casper RuudRuud (0-2) – H2H and prediction
• Cameron NorrieNorrie – Sebastian KordaKorda (1-3) – H2H and prediction
• Reilly OpelkaOpelka – Carlos Alcaraz GarfiaAlcaraz Garfia (0-0) – H2H and prediction
• Arthur RinderknechRinderknech – Alejandro Davidovich FokinaDavidovich Fokina (1-0) – H2H and prediction
• Benjamin BonziBonzi – Marcos GironGiron (0-0) – H2H and prediction
• Billy HarrisHarris – Felix Auger AliassimeAuger Aliassime (0-0) – H2H and prediction
• Daniel AltmaierAltmaier – (1-1) – H2H and prediction
• Frances TiafoeTiafoe – Yoshihito NishiokaNishioka (3-3) – H2H and prediction
• Stefanos TsitsipasTsitsipas – Alexandre MullerMuller (2-0) – H2H and prediction
• Jaume Antoni Munar ClarAntoni Munar Clar – (0-1) – H2H and prediction
• Lorenzo SonegoSonego – Tristan SchoolkateSchoolkate (0-0) – H2H and prediction
• Nuno BorgesBorges – Brandon HoltHolt (0-0) – H2H and prediction
• Alexei PopyrinPopyrin – Emil RuusuvuoriRuusuvuori (1-0) – H2H and prediction
• Federico Agustin GomezAgustin Gomez – Jack DraperDraper (0-0) – H2H and prediction
• Zizou BergsBergs – Chun Hsin TsengHsin Tseng (0-0) – H2H and prediction
• Ugo HumbertHumbert – Adam WaltonWalton (0-0) – H2H and prediction
• Aleksandar KovacevicKovacevic – (1-0) – H2H and prediction
• Jenson BrooksbyBrooksby – Aleksandar VukicVukic (1-1) – H2H and prediction
• Hugo GastonGaston – (1-1) – H2H and prediction
• Jannik SinnerSinner – Vit KoprivaKopriva (0-0) – H2H and prediction
• Sebastian BaezBaez – Lloyd HarrisHarris (0-0) – H2H and prediction
• Brandon NakashimaNakashima – (0-0) – H2H and prediction
• Jiri LeheckaLehecka – Tomas Martin EtcheverryMartin Etcheverry (1-2) – H2H and prediction
• Valentin RoyerRoyer – Bu YunchaoketeYunchaokete (1-0) – H2H and prediction
• Francisco ComesanaComesana – (0-0) – H2H and prediction
• Francesco PassaroPassaro – Flavio CobolliCobolli (0-1) – H2H and prediction
• Lorenzo MusettiMusetti – (2-0) – H2H and prediction
• Gabriel DialloDiallo – Damir DzumhurDzumhur (0-0) – H2H and prediction