Holger Rune and Botic Van De Zandschulp will play each other in the 1^st round of the U.S. Open for the 3^rd time in their career. They are scheduled to compete on Monday at 4:00 pm on Grandstand. In the following paragraphs, you can find the head to head analysis and prediction.

Prediction, odds and live streaming

The pick for Tennis Tonic is Holger Rune who should win in 3 sets.

As per the initial odds, Holger Rune is the pick to win this match.
Holger Rune -> 1.22
Botic Van De Zandschulp -> 4.3

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Prediction and head to head Holger Rune vs. Botic Van De Zandschulp

This will be the 3^rd time that Holger Rune and Botic Van De Zandschulp square off. The head to head is 2-0 for Rune (see full H2H stats), but they have never competed against each other on hard.

The last time that they competed against each other, Rune won 6-4 1-6 7-6(3) in the final in Munich back in 2023.

Highlights Holger Rune vs Botic Van De Zandschulp – Munich 23-April-2023

Holger Rune

Ranked no. 11, Holger will start his run at the U.S. Open after he played his last match in Cincinnati where he lost 6-2 6-3 to Atmane in the quarter on the 14^th of August.

Holger has an overall 27-16 win-loss record in 2025, 14-7 on hard (See FULL STATS).

His best result of the current season was winning the title in Barcelona where he beat Carlos Alcaraz in the final 7-6(6) 6-2.

Talking about his overall career, The Dane has an overall 278-146 record. He has a positive 65-49 record on hard.

Previously at the U.S. Open

Previously, his best result was reaching the 3^rd round in 2022. See his history.

Botic Van De Zandschulp

Ranked no. 92, will start his run at the New York after he played his last match in Winston Salem where he overcame 6-4 7-5 to Mpetshi in the semifinal on the 22^nd of August.

Van De Zandschulp has a composed 24-21 win-loss record in 2025, 12-6 on hard (See FULL STATS).

Van De Zandschulp’s best result of the season was reaching the semifinal in Kitzbuhel and Salem.

Van De Zandschulp won his last 5 matches.

In terms of his career, Botic has an overall 370-228 record. He has a positive 73-49 record on hard.

Previously at the U.S. Open

Previously, his best result was reaching the quarter in 2021. See his history.

Tennis Scores – U.S. Open

• Jerome KymKym – Yibing WuWu (6-3 6-2) – See score progression
• Zsombor PirosPiros – James DuckworthDuckworth (6-1 4-6 6-2) – See score progression
• Federico Agustin GomezAgustin Gomez – Hugo GrenierGrenier (6-7⁵ 7-6⁵ 6-2) – See score progression
• Francesco PassaroPassaro – Henrique RochaRocha (7-5 6-3) – See score progression
• Lloyd HarrisHarris – Daniel Merida AguilarMerida Aguilar (6-1 7-6²) – See score progression
• Chak Lam Coleman WongLam Coleman Wong – Billy HarrisHarris (6-3 6-4) – See score progression
• Martin DammDamm – Yuta ShimizuShimizu (7-6¹⁰ 6-4) – See score progression
• Jan-Lennard StruffStruff – Arthur CazauxCazaux (7-6⁴ 6-3) – See score progression
• Jesper De JongDe Jong – Mitchell KruegerKrueger (6-4 6-1) – See score progression
• Dino PrizmicPrizmic – Jason Murray KublerMurray Kubler (6-3 4-6 6-1) – See score progression
• Ignacio BuseBuse – Kimmer CoppejansCoppejans (6-3 6-4) – See score progression
• Ugo BlanchetBlanchet – Jaime FariaFaria (7-5 6-4) – See score progression
• Pablo Llamas RuizLlamas Ruiz – Marco TrungellitiTrungelliti (3-6 6-1 6-2) – See score progression
• Zachary SvajdaSvajda – Marc-Andrea HueslerHuesler (6-3 6-2) – See score progression
• Leandro RiediRiedi – Garrett JohnsJohns (7-6⁵ 6-4) – See score progression
• Shintaro MochizukiMochizuki – Daniel Elahi GalanElahi Galan (6-4 6-4) – See score progression

Upcoming matches in the draw

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• Novak DjokovicDjokovic – (0-0) – H2H and prediction
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• Hugo DellienDellien – Kamil Majchrzak
  Majchrzak (1-1) – H2H and prediction
• Roberto Carballes BaenaCarballes Baena – Arthur RinderknechRinderknech (2-0) – H2H and prediction
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• Alexander ZverevZverev – Alejandro TabiloTabilo (1-0) – H2H and prediction
• Laslo DjereDjere – (0-0) – H2H and prediction
• Alexander BublikBublik – Marin CilicCilic (0-3) – H2H and prediction
• Botic Van De ZandschulpVan De Zandschulp – Holger Vitus Nodskov RuneVitus Nodskov Rune (0-2) – H2H and prediction
• Christopher O ConnellO Connell – Alex De MinaurDe Minaur (0-0) – H2H and prediction
• Quentin HalysHalys – David GoffinGoffin (0-1) – H2H and prediction
• Karen KhachanovKhachanov – (0-0) – H2H and prediction
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• Jannik SinnerSinner – Vit KoprivaKopriva (0-0) – H2H and prediction
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