Daniil Medvedev and Reilly Opelka will play each other in the 2^nd round of the Citi Open for the 7^th time in their career. They are scheduled to compete on Wednesday at 12:30 pm on STADIUM. In this post, we analyze their head to head performance and prediction.

Prediction, odds and live streaming

The pick for Tennis Tonic is Daniil Medvedev who should win in 2 sets.

As per the initial odds, Daniil Medvedev is the pick to win this match.
Daniil Medvedev -> 1.32
Reilly Opelka -> 3.38

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Prediction and head to head Daniil Medvedev vs. Reilly Opelka

This will be the 7^th time that Daniil Medvedev and Reilly Opelka fight against each other. The head to head is 4-2 for Medvedev (see full H2H stats), 3-0 on hard.

The last time that they locked horns, Opelka won 7-6(5) 7-6(5) in the quarter in S hertogenbosch back in June 2025.

Highlights Reilly Opelka vs Daniil Medvedev – S hertogenbosch 13-June-2025

Daniil Medvedev

Ranked no. 14, the Russian will start his run in Washington after he played his last match at Wimbledon where he lost 7-6(2) 3-6 7-6(3) 6-2 to Bonzi in the 1^st round on the 30^th of June.

The Russian has an overall 23-14 win-loss record in 2025, 9-5 on hard (See FULL STATS).

Medvedev’s best result of the current year was reaching the final in Halle.

Talking about his overall career, Medvedev has an overall 559-233 record. He has a positive 256-84 record on hard.

Previously in Washington

Previously, his best result was reaching the final in 2019. See his history.

Reilly Opelka

Ranked no. 74, Reilly reached the 2^nd round after beating Murphy Cassone 7-6(4) 6-7(5) 6-3.

In the 1^st round, The American defeated Cassone (7-6⁴ 6-7⁵ 6-3). During the match Opelka scored 110 points vs Cassone’s 98. Reilly was quite aggressive to blast 53 winners.

About the serving games, Opelka buried his opponent with 23 aces and he committed only 3 double faults. Overall, Reilly Opelka was exceptionally efficient on serve to win 87% (53/61) of his 1st serve and 57% (27/47) on the second serve. However, this didn’t prevent his to concede the serve once. Reilly broke Cassone twice after converting 33% of his break points (2/6).

Reilly’s best result of the season was getting to the final in Brisbane.

The American has a compiled 24-18 win-loss record in 2025, 10-6 on hard (See FULL STATS).

Previously in Washington

Previously, his best result was reaching the 3^rd round in 2021 and 2022. See his history.

Tennis Scores in Washington

• Cameron NorrieNorrie – Lorenzo MusettiMusetti (3-6 6-2 6-3) – Stats, scores, rankings
• Gabriel DialloDiallo – Fabian MarozsanMarozsan (6-3 6-4) – Stats, scores, rankings
• Brandon NakashimaNakashima – Ethan QuinnQuinn (6-3 6-4) – Stats, scores, rankings
• Gabriel DialloDiallo – Fabian MarozsanMarozsan (6-3 6-4) – Stats, scores, rankings

Upcoming matches in the draw

• Daniil MedvedevMedvedev – Reilly OpelkaOpelka (4-2) – H2H and prediction
• Alexandre MullerMuller – Holger Vitus Nodskov RuneVitus Nodskov Rune (0-1) – H2H and prediction
• Taylor Harry FritzHarry Fritz – Aleksandar VukicVukic (2-0) – H2H and prediction
• Alejandro Davidovich FokinaDavidovich Fokina – Jaume Antoni Munar ClarAntoni Munar Clar (2-2) – H2H and prediction
• Aleksandar KovacevicKovacevic – Frances TiafoeTiafoe (0-2) – H2H and prediction
• Alex De MinaurDe Minaur – Bu YunchaoketeYunchaokete (1-0) – H2H and prediction
• Yibing WuWu – Alexei PopyrinPopyrin (0-1) – H2H and prediction
• Brandon NakashimaNakashima – Cameron NorrieNorrie (1-3) – H2H and prediction
• Flavio CobolliCobolli – Yoshihito NishiokaNishioka (1-1) – H2H and prediction