Serena has just won the title in Key Biscane to immediately play quite a competitive tournament in Charleston as the defending champion.
The top seeds are Serena Williams, Wozniacki, Stosur, Stephens, Venus Williams, Safarova, Suarez Navarro, Barthel, Jankovic, Goerges, Cirstea, Lepchenko, Pasek, Shvedova, Lisicki and Laura Robson.
The pick is obviously Serena if not tired or injured.
Here a quick look to the draws
1st Half Serena
| Round | Opponent | Head to Head |
| 1st | Bye | |
| 2nd | Giorgi | 1st time playing |
| 3rd | Lisiki | 2-0 Serena |
| Quarters | Safarova | 5-0 Serena. Last time they played it was in last year final in Charleston when Serena won 6-0 6-1 |
| Semifinal | Stephens | 1-1. Sloane on the last one in Melbourne |
| Final | Wozniacki | 5-1 for Serena |
2nd Half Wozniacki
| Round | Opponent | Head to Head |
| 1st | Bye | |
| 2nd | Schiavone | 5-2 Wozniacki that has won the last 5. |
| 3rd | Shvedova | 1st time playing |
| Quarters | Goerges | 3-2 Goerges that has won the last 3. |
| Semifinal | Stosur | 3-3. |
| Final | Wozniacki | 5-1 for Serena |